Indicative contents

• Fundamentals of mass and heat transport as related to living systems. Convection, diffusion, active transport and osmosis. Application of conservation of mass, momentum and energy equations as applied to cellular and organ level transport.
  
• Micro- and Macrocirculation. Major features of microcirculation. Rheological properties of blood. Pulmonary capillary blood flow.
  
• Respiratory Gas Flow. Gas flow in an airway. Interaction between convection and diffusion. Exchange processes in the lung. Ventilation and Pulmonary function tests. Dynamics of the ventilation system.
  
• Transport in membranes. Gibbs and Gibbs-Duhem equations. Chemical potential and entropy. Transport across cell membranes.
  
• Mass Transport in capillaries Tissues and Interstitial spaces. Transport across vessel wall. Fluid movement in the tissues and interstitial space. Measurements.
  
• Physical mechanisms involved in biological events in natural and artificial surfaces exposed to biological fluids. Role of fluid mechanics in atherosclerosis.
  
• Lymph flow.
  
• Peristaltic motion.
  
• Renal flow. Dialysis. Endocrine systems. Evaluation of the system performance.
  
• Artificial organs. Artificial liver and pancreas.
  
• Local application of medicines and their influence. Glucose loading and influence of insulin.
  
• Bioenvironmental heat transfer..

Recommended reading

• Books
  1. Y.C. Fung. Biomechanics: Circulation. Springer, 1997.
  2. D.J. Patel & R.N. Vaishnav. Basic Hemodynamics and its Role in Disease Processes. University Park Press, 1980.
  3. G. Pedrizzetti & K. Perktold. Cardiovascular Fluid Mechanics. Springer Wien New York, 2003.
  4. Y.C. Fung. Biomechanics: Motion, Flow, Stress, and Growth. Springer, 1990.
  5. Y.C. Fung. Biomechanics: Mechanical Properties of Living Tissue. Springer, 1993.
  6. C.A.Phillips. Human Factors Engineering. Wiley, 1999.
  7. Myer Kutz,, Standard Handbook of Biomedical Engineering & Design, McGrawhill 2003.
  8. John Enderle, Susan Blanchard and Joseph Bronzino, Introduction to Biomedical Engineering, Academic Press, 2005.

   

• Journals
  1. J. of Biomechanics.
  2. American J. of Physiology.
  3. Arteriosclerosis.
  4. ASME J. of Biomechanical Engg.
  5. Circulation Research.
  6. Annual Review of Physiology.
  7. Biorheology.
  8. Journal of Fluid Mechanics. (For general Fluid Mechanics interest.)
  9. Physics of Fluids. (For general Fluid Mechanics interest.)
  10. Experiments in Fluids. (For general Fluid Mechanics interest.)

   

• Laboratory:
  1. Hardware: PC
  2. Software: MATLAB, CFD Software, Fluent
  3. Software Manuals: ,MATLAB User Manual, Fluent Manual